How to use the Epinephrine Injection?

Read the Instructions for Use carefully before you use epinephrine injection and each time you get a refill. There may be new information. Before you need to use your epinephrine injection, make sure your healthcare provider shows you the right way to use it. Patients, caregivers and others who may be in a position to administer epinephrine injection should also understand how to use it well. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. If you have any questions, ask your healthcare provider.

In addition, our free Trainers let you practice using an injector properly without an injection occurring.

How to use the Epinephrine Injection?

Read the Instructions for Use carefully before you use epinephrine injection and each time you get a refill. There may be new information. Before you need to use your epinephrine injection, make sure your healthcare provider shows you the right way to use it. Patients, caregivers and others who may be in a position to administer epinephrine injection should also understand how to use it well. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. If you have any questions, ask your healthcare provider.

In addition, our free Trainers let you practice using an injector properly without an injection occurring.

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Please watch the instructional video

Take the time to view this now, so you’ll know exactly how to use your epinephrine auto-injector in an emergency. This information does not replace talking with your doctor about your medical condition or your treatment.

Instructions for using the Epinephrine Injection for both the epinephrine auto-injector 0.15 mg and the epinephrine auto-injector 0.3mg.

Figure A

STEP 1.   Prepare epinephrine injection for injection

Remove epinephrine injection from its protective carrying case. See Figure A.

Figure B

Pull off blue end caps; you will now see a red tip. Grasp the auto-injector in your fist with the red tip pointing downward. See Figure B.

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Note

The needle comes out of the red tip. To avoid an accidental injection, never put your thumb, fingers, or hand over the red tip. If an accidental injection happens, get medical help right away.

Figure C

STEP 2.   Administer epinephrine injection

If you are administering epinephrine injection to a young child, hold the leg firmly in place and limit movement prior to and while administering an injection. Put the red tip against the middle of the outer thigh (upper leg) at a 90° angle (perpendicular) to the thigh. Press down hard and hold firmly against the thigh for approximately 10 seconds to deliver the medicine. See Figure C. 

Only inject into the middle of the outer thigh. Do not inject into any other part of the body. Remove epinephrine injection from the thigh. Massage the area for 10 seconds. Check the red tip. The injection is complete and you have received the correct dose of the medicine if you see the needle sticking out of the red tip. If you do not see the needle repeat Step 2.

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STEP 3.   

Get emergency medical help right away.

You may need further medical attention. You may need to use a second epinephrine injection if symptoms continue or recur.

Figure D

STEP 4.   After use/disposal

Carefully cover the needle with the carrying case. Lay the labeled half of the carrying case cover down on a flat surface. Use one hand to carefully slide the end of epinephrine injection, needle first, into the labeled carrying case cover. See Figure D.

Figure E

After the needle is inside the labeled cover, push the unlabeled half of the carrying case cover firmly over the non-needle end of epinephrine injection. See Figure E. Take your used epinephrine injection with you when you go to see a healthcare provider. Tell the healthcare provider that you have received an injection of epinephrine. Show the healthcare provider where you received the injection. Give your used epinephrine injection to the healthcare provider for inspection and proper disposal.

Ask for a refill, if needed.

Notes
        • Epinephrine injection is a single-use injectable device that delivers a fixed dose of epinephrine. Epinephrine injection cannot be reused. Do not attempt to reuse epinephrine injection after the device has been activated. It is normal for most of the medicine to remain in the auto-injector after the dose is injected. The correct dose has been administered if you see the needle sticking out of thered tip.

        • A separate epinephrine injection Trainer is available. The epinephrine injection Trainer has a beige color. The beige epinephrine injection Trainer contains no medicine and no needle. Practice with your epinephrine injection Trainer, but always carry your real epinephrine injection in case of an allergic emergency.

        • If you will be administering epinephrine injection to a young child, ask your healthcare provider to show you how to properly hold the leg in place while administering a dose.

        • Do not try to take the epinephrine injection apart.

        • Each single-dose epinephrine injection is designed to provide accurate delivery of a complete dose of epinephrine when it is needed most.

        • Since you cannot predict when a life-threatening allergic reaction (anaphylaxis) will occur, carry your epinephrine injection at all times.

        • Remember, after using the epinephrine injection, you must obtain emergency medical treatment right away.

Tips
      • The two blue end caps help to prevent accidental injection.Do NOT remove the blue caps until you’re ready to use epinephrine injection.
      • Store epinephrine injection at room temperature between 68°-77°F (20°-25°C). Do not expose to extreme heat or cold. For example, do not store in your vehicle’s glove box or in the refrigerator or freezer.
      • Protect from light.
      • Examine the contents in the viewing window of your epinephrine injection periodically. The solution should be clear. If the solution is discolored (pinkish or brown), cloudy or contains solid particles, replace the unit.
      • Always keep your epinephrine injection in the carrying case to protect it from damage. The carrying case is not waterproof.
      • If an accidental injection happens, get medical help right away.
Notes
          • Epinephrine injection is a single-use injectable device that delivers a fixed dose of epinephrine. Epinephrine injection cannot be reused. Do not attempt to reuse epinephrine injection after the device has been activated. It is normal for most of the medicine to remain in the auto-injector after the dose is injected. The correct dose has been administered if you see the needle sticking out of thered tip.

          • A separate epinephrine injection Trainer is available. The epinephrine injection Trainer has a beige color. The beige epinephrine injection Trainer contains no medicine and no needle. Practice with your epinephrine injection Trainer, but always carry your real epinephrine injection in case of an allergic emergency.

          • If you will be administering epinephrine injection to a young child, ask your healthcare provider to show you how to properly hold the leg in place while administering a dose.

          • Do not try to take the epinephrine injection apart.

          • Each single-dose epinephrine injection is designed to provide accurate delivery of a complete dose of epinephrine when it is needed most.

          • Since you cannot predict when a life-threatening allergic reaction (anaphylaxis) will occur, carry your epinephrine injection at all times.

          • Remember, after using the epinephrine injection, you must obtain emergency medical treatment right away.

Tips
        • The two blue end caps help to prevent accidental injection.Do NOT remove the blue caps until you’re ready to use epinephrine injection.
        • Store epinephrine injection at room temperature between 68°-77°F (20°-25°C). Do not expose to extreme heat or cold. For example, do not store in your vehicle’s glove box or in the refrigerator or freezer.
        • Protect from light.
        • Examine the contents in the viewing window of your epinephrine injection periodically. The solution should be clear. If the solution is discolored (pinkish or brown), cloudy or contains solid particles, replace the unit.
        • Always keep your epinephrine injection in the carrying case to protect it from damage. The carrying case is not waterproof.
        • If an accidental injection happens, get medical help right away.
      •  

IMPORTANT SAFETY INFORMATION

Anaphylaxis can be life threatening, can happen within minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or unknown causes. Always carry your epinephrine injection with you because you may not know when anaphylaxis may happen.

When you have an allergic emergency (anaphylaxis)

  • Use epinephrine injection right away.
  • Get emergency medical help right away. You may need further medical attention. You may need to use a second epinephrine injection if symptoms continue or recur. Only a healthcare provider should give additional doses of epinephrine if you need more than 2 injections for a single anaphylaxis episode.

Epinephrine injection should only be injected into the middle of your outer thigh (upper leg). Do not inject the epinephrine injection into your: veins, buttocks, fingers, toes, hands, or feet. If you accidentally inject epinephrine injection into any other part of your body, go to the nearest emergency room right away. Tell the healthcare provider where on your body you received the accidental injection.

Rarely, people who have used epinephrine injection may develop infections at the injection site within a few days of an injection. Some of these infections can be serious. Call your healthcare provider right away if you have any of the following at an injection site: redness that does not go away, swelling, tenderness, or the area feels warm to the touch.

Cuts on the skin, bent needles, and needles that remain in the skin after the injection, have happened in young children who do not cooperate and kick or move during an injection. If you inject a young child with epinephrine injection, hold their leg firmly in place before and during the injection to prevent injuries. Ask your healthcare provider to show you how to properly hold the leg of a young child during injection.

If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use epinephrine injection. Tell your healthcare provider about all your medical conditions.

Common side effects of epinephrine injection include: faster, irregular or “pounding” heartbeat; sweating; headache; weakness; shakiness; paleness; feelings of over excitement, nervousness or anxiety; dizziness; nausea and vomiting; and breathing problems. These side effects may go away with rest.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of epinephrine injection. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

APPROVED USE

Epinephrine injection is a disposable, prefilled automatic injection device (auto-injector) used to treat life-threatening, allergic emergencies including anaphylaxis in people who are at risk for or have a history of serious allergic emergencies. Each device contains a single dose of epinephrine.

Epinephrine injection is for immediate self (or caregiver) administration and does not take the place of emergency medical care. You should get emergency help right away after using epinephrine injection.

The epinephrine injection 0.3 mg is for patients who weigh 66 pounds or more (30 kilograms or more). The epinephrine injection 0.15 mg is for patients who weigh about 33 to 66 pounds (15 to 30 kilograms). It is not known if epinephrine injection is safe and effective in children who weigh less than 33 pounds (15 kilograms).

Please read the Patient Information and Instructions for Use in the accompanying Full Prescribing Information.

 

IMPORTANT SAFETY INFORMATION
Anaphylaxis can be life threatening, can happen within minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or unknown causes. Always carry your epinephrine injection with you because you may not know when anaphylaxis may happen. When you have an allergic emergency (anaphylaxis)

  • Use epinephrine injection right away.
  • Get emergency medical help right away. You may need further medical attention. You may need to use a second epinephrine injection if symptoms continue or recur. Only a healthcare provider should give additional doses of epinephrine if you need more than 2 injections for a single anaphylaxis episode.
Epinephrine injection should only be injected into the middle of your outer thigh (upper leg). Do not inject the epinephrine injection into your: veins, buttocks, fingers, toes, hands, or feet. If you accidentally inject epinephrine injection into any other part of your body, go to the nearest emergency room right away. Tell the healthcare provider where on your body you received the accidental injection. Rarely, people who have used epinephrine injection may develop infections at the injection site within a few days of an injection. Some of these infections can be serious. Call your healthcare provider right away if you have any of the following at an injection site: redness that does not go away, swelling, tenderness, or the area feels warm to the touch. Cuts on the skin, bent needles, and needles that remain in the skin after the injection, have happened in young children who do not cooperate and kick or move during an injection. If you inject a young child with epinephrine injection, hold their leg firmly in place before and during the injection to prevent injuries. Ask your healthcare provider to show you how to properly hold the leg of a young child during injection. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use epinephrine injection. Tell your healthcare provider about all your medical conditions. Common side effects of epinephrine injection include: faster, irregular or “pounding” heartbeat; sweating; headache; weakness; shakiness; paleness; feelings of over excitement, nervousness or anxiety; dizziness; nausea and vomiting; and breathing problems. These side effects may go away with rest. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of epinephrine injection. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. APPROVED USE Epinephrine injection is a disposable, prefilled automatic injection device (auto-injector) used to treat life-threatening, allergic emergencies including anaphylaxis in people who are at risk for or have a history of serious allergic emergencies. Each device contains a single dose of epinephrine. Epinephrine injection is for immediate self (or caregiver) administration and does not take the place of emergency medical care. You should get emergency help right away after using epinephrine injection. The epinephrine injection 0.3 mg is for patients who weigh 66 pounds or more (30 kilograms or more). The epinephrine injection 0.15 mg is for patients who weigh about 33 to 66 pounds (15 to 30 kilograms). It is not known if epinephrine injection is safe and effective in children who weigh less than 33 pounds (15 kilograms). Please read the Patient Information and Instructions for Use in the accompanying Full Prescribing Information.  >
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