About Anaphylaxis

What is anaphylaxis?

Anaphylaxis is a potentially life-threatening allergic reaction that is rapid in onset and may cause severe swelling, itching, skin rash, breathing problems, and loss of blood pressure.*†‡§

What causes anaphylaxis?

Anaphylaxis can be caused by common, everyday “Anaphylaxis Phyl” allergens like latex, stinging and biting insects, allergy injections, foods, medicines, or other unknown causes.§
  • Source: Lieberman P, Nicklas R, Randolph C, et al. Anaphylaxis—a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015;115:341-384.
  • Source: Sampson HA, Muñoz-Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006;117(2):391-397.
  • Source: Simons FER. Anaphylaxis. J Allergy Clin Immunol. 2010;125(suppl 2):S161-S181.
  • Source: Epinephrine injection, USP auto-injector [package insert]. Bridgewater, NJ: Amneal Pharmaceuticals; 2021.

Always be prepared for Anaphylaxis Phyl and the all-too-common “what-ifs” who trigger him.

You should know…

Who are some of my common pals who can cause anaphylaxis? Peanuts, Bee Stings, Shellfish, Medications, Dairy, Latex, and more…*

What are some of the signs and symptoms of anaphylaxis?

About anaphylaxis

What is Anaphylaxis?

Anaphylaxis is a potentially life-threatening allergic reaction that is rapid in onset and may cause severe swelling, breathing problems, loss of blood pressure, and death.*§

What causes anaphylaxis?

Anaphylaxis can be caused by common, everyday “what-if” allergens latex, stinging and biting insects, allergy injections, food, medicines, or other unknown causes.§

Always be prepared for all the common, everyday Phyl that may pop up.

You should know…

Epinephrine, is the medicine of choice for someone experiencing an anaphylactic reaction.*†‡§

Because anaphylaxis happens quickly, prompt recognition of the signs and symptoms of anaphylaxis is crucial.*

IMPORTANT SAFETY INFORMATION

Epinephrine injection, USP auto-injector is intended for immediate administration as emergency supportive
therapy and is not intended as a substitute for immediate medical care. In conjunction with the administration of
epinephrine, the patient should seek immediate medical or hospital care. More than two sequential doses of
epinephrine should only be administered under direct medical supervision.

Epinephrine injection, USP auto-injector should ONLY be injected into the anterolateral aspect of the thigh. Do not
inject intravenously. Do not inject into buttock. Do not inject into fingers, hands or feet. Instruct caregivers to
hold the child’s leg firmly in place and limit movement prior to and during injection to minimize the risk of injection
related injury.

Epinephrine should be administered with caution to patients who have heart disease, including patients with
cardiac arrhythmias, coronary artery or organic heart disease, or hypertension. In such patients, or in patients who
are on drugs that may sensitize the heart to arrhythmias, epinephrine may precipitate or aggravate angina pectoris
as well as produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported
in patients with underlying cardiac disease or those receiving certain drugs. Patients who receive epinephrine
while concomitantly taking cardiac glycosides, diuretics or anti-arrhythmics should be observed carefully for the
development of cardiac arrhythmias. Epinephrine should be administered with caution to patients with
hyperthyroidism, diabetes, elderly individuals, and pregnant women. Patients with Parkinson’s disease may notice
a temporary worsening of symptoms.

Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by
Clostridia, have been reported at the injection site following epinephrine injection for anaphylaxis. Advise patients
to seek medical care if they develop signs or symptoms of infection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about epinephrine injection, USP auto-injector?

  1. Epinephrine injection, USP auto-injector contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen within minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise or other unknown causes. Symptoms of anaphylaxis may include:
    • trouble breathing
    • wheezing
    • hoarseness (changes in the way your voice sounds)
    • hives (raised reddened rash that may itch)
    • severe itching
    • swelling of your face, lips, mouth, or tongue
    • skin rash, redness, or swelling
    • fast heartbeat
    • weak pulse
    • feeling very anxious
    • confusion
    • stomach pain
    • losing control of urine or bowel movements (incontinence)
    • diarrhea or stomach cramps
    • dizziness, fainting, or “passing out” (unconsciousness).
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