Who are some of my common pals who can cause anaphylaxis?

What are the signs and symptoms of anaphylaxis?

The signs and symptoms of anaphylaxis may begin within seconds or minutes of exposure to an Anaphylaxis Phyl allergen.

In certain situations, symptoms may develop more than 30 minutes later.*

Symptoms of anaphylaxis may include:

  • Trouble breathing
  • Wheezing
  • Hoarseness (changes in the way your voice sounds)
  • Hives (raised, reddened rash that may itch)
  • Severe itching
  • Swelling of your face, lips, mouth, or tongue
  • Skin rash, redness, or swelling
  • Fast heartbeat
  • Weak pulse
  • Feeling very anxious
  • Confusion
  • Stomach pain
  • Losing control of urine or bowel movements (incontinence)
  • Diarrhea or stomach cramps
  • Dizziness, fainting, or “passing out” (unconsciousness)
  • Source: Lieberman P, Nicklas R, Randolph C, et al. Anaphylaxis a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015;115:341-384.

What are the signs and symptoms of anaphylaxis?

The signs and symptoms of anaphylaxis may begin within seconds or minutes of exposure to a “what-if” allergen.

In certain situations, symptoms may develop more than 30 minutes later.*

Symptoms of anaphylaxis may include:

  • Trouble breathing
  • Wheezing
  • Hoarseness (changes in the way your voice sounds)
  • Hives (raised, reddened rash that may itch)
  • Severe itching
  • Swelling of your face, lips, mouth, or tongue
  • Skin rash, redness, or swelling
  • Fast heartbeat
  • Trouble breathing
  • Wheezing
  • Hoarseness (changes in the way your voice sounds)
  • Hives (raised, reddened rash that may itch)
  • Severe itching
  • Swelling of your face, lips, mouth, or tongue
  • Skin rash, redness, or swelling
  • Fast heartbeat
  • Weak pulse
  • Feeling very anxious
  • Confusion
  • Stomach pain
  • Losing control of urine or bowel movements (incontinence)
  • Diarrhea or stomach cramps
  • Dizziness, fainting, or “passing out” (unconsciousness)
  • Weak pulse
  • Feeling very anxious
  • Confusion
  • Stomach pain
  • Losing control of urine or bowel movements (incontinence)
  • Diarrhea or stomach cramps
  • Dizziness, fainting, or “passing out” (unconsciousness)

*Source: Lieberman P, Nicklas R, Randolph C, et al. Anaphylaxis a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015;115:341-384.

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Note

Epinephrine injection, USP auto-injector is for immediate self (or caregiver) administration and does not take the place of emergency medical care. You should get emergency medical help right away after using epinephrine injection, USP auto-injector.

Please see your healthcare provider for more information on anaphylaxis and potential triggers that may cause it.

Talk to your healthcare provider about always being prepared to respond to an allergic emergency (anaphylaxis) by using your epinephrine auto-injector right away.

Talk to your healthcare provider about always being prepared to respond to an allergic emergency (anaphylaxis) by using your epinephrine auto-injector right away.

IMPORTANT SAFETY INFORMATION

Epinephrine injection, USP auto-injector is intended for immediate administration as emergency supportive
therapy and is not intended as a substitute for immediate medical care. In conjunction with the administration of
epinephrine, the patient should seek immediate medical or hospital care. More than two sequential doses of
epinephrine should only be administered under direct medical supervision.

Epinephrine injection, USP auto-injector should ONLY be injected into the anterolateral aspect of the thigh. Do not
inject intravenously. Do not inject into buttock. Do not inject into fingers, hands or feet. Instruct caregivers to
hold the child’s leg firmly in place and limit movement prior to and during injection to minimize the risk of injection
related injury.

Epinephrine should be administered with caution to patients who have heart disease, including patients with
cardiac arrhythmias, coronary artery or organic heart disease, or hypertension. In such patients, or in patients who
are on drugs that may sensitize the heart to arrhythmias, epinephrine may precipitate or aggravate angina pectoris
as well as produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported
in patients with underlying cardiac disease or those receiving certain drugs. Patients who receive epinephrine
while concomitantly taking cardiac glycosides, diuretics or anti-arrhythmics should be observed carefully for the
development of cardiac arrhythmias. Epinephrine should be administered with caution to patients with
hyperthyroidism, diabetes, elderly individuals, and pregnant women. Patients with Parkinson’s disease may notice
a temporary worsening of symptoms.

Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by
Clostridia, have been reported at the injection site following epinephrine injection for anaphylaxis. Advise patients
to seek medical care if they develop signs or symptoms of infection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about epinephrine injection, USP auto-injector?

  1. Epinephrine injection, USP auto-injector contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen within minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise or other unknown causes. Symptoms of anaphylaxis may include:
    • trouble breathing
    • wheezing
    • hoarseness (changes in the way your voice sounds)
    • hives (raised reddened rash that may itch)
    • severe itching
    • swelling of your face, lips, mouth, or tongue
    • skin rash, redness, or swelling
    • fast heartbeat
    • weak pulse
    • feeling very anxious
    • confusion
    • stomach pain
    • losing control of urine or bowel movements (incontinence)
    • diarrhea or stomach cramps
    • dizziness, fainting, or “passing out” (unconsciousness).
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