Epinephrine Side Effects

Before you use epinephrine injection, USP auto-injector, tell your healthcare provider about all your medical conditions, especially if you:
  • Have heart problems or high blood pressure
  • Have diabetes
  • Have thyroid problems
  • Have asthma
  • Have a history of depression
  • Have Parkinson’s disease
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. It is not known if epinephrine will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if epinephrine passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Tell your healthcare provider of all known allergies to possibly avoid epinephrine side effects.

Epinephrine injection, USP auto-injector should only be injected into the middle of your outer thigh (upper leg). Do not inject epinephrine injection, USP auto-injector into your:
  • Veins
  • Buttocks
  • Fingers, toes, hands or feet
  • If you accidently inject epinephrine injection, USP auto-injector into any other part of you body, go to the nearest emergency room right away. Tell the healthcare provider where on your body you received the accidental injection.
Rarely, patients who use epinephrine injection, USP auto-injector may develop infections at the injection site within a few days of an injection. Some of these infections can be serious. Call your healthcare provider right away if you have any of the following at an injection site:
  • Redness that does not go away
  • Swelling
  • Tenderness
  • The area feels warm to the touch
Common side effects of epinephrine injection, USP auto-injector include:
  • Faster, irregular or “pounding” heartbeat
  • Sweating
  • Headache
  • Weakness
  • Shakiness
  • Paleness
  • Feelings of over excitement, nervousness, or anxiety
  • Dizziness
  • Nausea or vomiting
  • Breathing problems

These side effects may go away with rest. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of epinephrine injection, USP auto-injector. For more information, ask your healthcare provider or pharmacist.

Safety

Before you use epinephrine injection, USP auto-injector, tell your healthcare provider about all your medical conditions, especially if you:
  • Have heart problems or high blood pressure
  • Have diabetes
  • Have thyroid problems
  • Have asthma
  • Have a history of depression
  • Have Parkinson’s disease
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. It is not known if epinephrine will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if epinephrine passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Tell your healthcare provider of all known allergies.

Epinephrine injection, USP auto-injector should only be injected into the middle of your outer thigh (upper leg). Do not inject epinephrine injection, USP auto-injector into your:
  • Veins
  • Buttocks
  • Fingers, toes, hands or feet
  • If you accidently inject epinephrine injection, USP auto-injector into any other part of you body, go to the nearest emergency room right away. Tell the healthcare provider where on your body you received the accidental injection.
Rarely, patients who use epinephrine injection, USP auto-injector may develop infections at the injection site within a few days of an injection. Some of these infections can be serious. Call your healthcare provider right away if you have any of the following at an injection site:
  • Redness that does not go away
  • Swelling
  • Tenderness
  • The area feels warm to the touch
Common side effects of epinephrine injection, USP auto-injector include:
  • Faster, irregular or “pounding” heartbeat
  • Sweating
  • Headache
  • Weakness
  • Shakiness
  • Paleness
  • Feelings of over excitement, nervousness, or anxiety
  • Dizziness
  • Nausea or vomiting
  • Breathing problems

These side effects may go away with rest. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of epinephrine injection, USP auto-injector. For more information, ask your healthcare provider or pharmacist.

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Epinephrine injection, USP auto-injector and other medicines may affect each other, causing side effects. Epinephrine injection, USP auto-injector may affect the way other medicines work, and other medicines may affect how epinephrine injection, USP auto-injector works. Talk to your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider of all known allergies.

When Anaphylaxis Phyl’s “what-if” friends pop up, always be prepared with a low-cost Epinephrine Injection, USP Auto-Injector.

When Anaphylaxis Phyl’s “what-if” friends pop up, always be prepared with a low-cost Epinephrine Injection, USP Auto-Injector.

IMPORTANT SAFETY INFORMATION

Epinephrine injection, USP auto-injector is intended for immediate administration as emergency supportive
therapy and is not intended as a substitute for immediate medical care. In conjunction with the administration of
epinephrine, the patient should seek immediate medical or hospital care. More than two sequential doses of
epinephrine should only be administered under direct medical supervision.

Epinephrine injection, USP auto-injector should ONLY be injected into the anterolateral aspect of the thigh. Do not
inject intravenously. Do not inject into buttock. Do not inject into fingers, hands or feet. Instruct caregivers to
hold the child’s leg firmly in place and limit movement prior to and during injection to minimize the risk of injection
related injury.

Epinephrine should be administered with caution to patients who have heart disease, including patients with
cardiac arrhythmias, coronary artery or organic heart disease, or hypertension. In such patients, or in patients who
are on drugs that may sensitize the heart to arrhythmias, epinephrine may precipitate or aggravate angina pectoris
as well as produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported
in patients with underlying cardiac disease or those receiving certain drugs. Patients who receive epinephrine
while concomitantly taking cardiac glycosides, diuretics or anti-arrhythmics should be observed carefully for the
development of cardiac arrhythmias. Epinephrine should be administered with caution to patients with
hyperthyroidism, diabetes, elderly individuals, and pregnant women. Patients with Parkinson’s disease may notice
a temporary worsening of symptoms.

Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by
Clostridia, have been reported at the injection site following epinephrine injection for anaphylaxis. Advise patients
to seek medical care if they develop signs or symptoms of infection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about epinephrine injection, USP auto-injector?

  1. Epinephrine injection, USP auto-injector contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen within minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise or other unknown causes. Symptoms of anaphylaxis may include:
    • trouble breathing
    • wheezing
    • hoarseness (changes in the way your voice sounds)
    • hives (raised reddened rash that may itch)
    • severe itching
    • swelling of your face, lips, mouth, or tongue
    • skin rash, redness, or swelling
    • fast heartbeat
    • weak pulse
    • feeling very anxious
    • confusion
    • stomach pain
    • losing control of urine or bowel movements (incontinence)
    • diarrhea or stomach cramps
    • dizziness, fainting, or “passing out” (unconsciousness).
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