1. Lieberman P, Kemp SF, Oppenheimer J, et al. The diagnosis and management of anaphylaxis: An updated practice parameter. J Allergy Clin Immunol. 2005;115(3):S483-S523.
  2. Sampson HA, Muñoz-Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: summary report–Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium. J Allergy Clin Immunol. 2006;117(2):391-397.
  3. Simons FER. Anaphylaxis. J Allergy Clin Immunol. 2010;125(suppl 2):S161-S181.
  4. Epinephrine injection, USP auto-injector. Patient Information Leaflet. Lineage Therapeutics, Horsham, PA: May 2013.
  5. Moffitt JE, Golden DB, Reisman RE, et al. Stinging insect hypersensitivity: A practice parameter update. J Allergy Clin Immunol. 2004;114:869-886.
  6. The Food Allergy & Anaphylaxis Network. Tips for Managing Food Allergies. www.foodallergy.org/section/tips-for-managing-food-allergies. Accessed February 23, 2013.
  7. American College of Allergy, Asthma & Immunology. Insect Sting Allergy. www.acaai.org/allergist/allergies/Types/insect-sting-allergies/Pages/default.aspx Accessed February 20, 2013.
  8. American College of Allergy, Asthma & Immunology. Drug Reactions and Drug Allergies. www.acaai.org/allergist/allergies/Types/drug-allergy/Pages/default.aspx Accessed February 20, 2013.
  9. American Latex Allergy Association. Common Latex Products. www.latexallergyresources.org/print/common-latex-products Accessed February 20, 2013.
  10. Epinephrine injection, USP auto-injector. Prescribing Information. Lineage Therapeutics, Horsham, PA. April 2013.
  11. Neugut AI, Ghatak AT, et al. Anaphylaxis in the United States: An investigation into its epidemiology. Arch Intern Med. 2001;161(1):15-21. archinte.jamanetwork.com/article.aspx?articleid=646961 Accessed March 1, 2013.
  12. Sicherer SH, Simons FER. Quandaries in prescribing an emergency action plan and self-injectable epinephrine for first-aid management of anaphylaxis in the community. J Allergy Clin Immunol. 2005;115(3):575-583.
  13. Boyce JA. Assa’ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: Report of the NIAID-sponsored Expert Panel. J Allergy Clin Immunol. 2010;126(suppl 6):S1-S58.

Indication

  • Epinephrine auto-injector is an emergency injection ("shot") of epinephrine. It is a medicine used for life-threatening allergic reactions such as severe swelling, breathing problems, or loss of blood pressure. Allergic reactions can be caused by stinging and biting insects (bugs), allergy injections, food, medicines, exercise, or unknown causes.
  • After using epinephrine auto-injector go to your doctor or emergency room right away for more medical treatment.

Important Safety Information

  • Make sure to tell your doctor about all your medical conditions and allergies, but especially if you:
    • have heart disease or high blood pressure
    • have diabetes
    • have thyroid conditions
    • have asthma
    • have depression or other mental disease
    • have Parkinson's disease
    • are pregnant
    • are allergic to any of the ingredients in epinephrine auto-injector
  • Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Some medicines may cause serious side effects if taken while you use epinephrine auto-injector. Some medicines may affect how epinephrine auto-injector works, or epinephrine auto-injector may affect how your other medicines work. Diabetic patients may need to adjust the dose of their diabetes medicines or insulin after using epinephrine auto-injector.
  • Avoid injecting epinephrine auto-injector into your buttock or any other part of your body, other than the middle of the outer side of your thigh (upper leg). Avoid injecting epinephrine auto-injector into a vein.
  • Too much epinephrine (epinephrine auto-injector) can cause dangerously high blood pressure, stroke, or death. If you take certain medicines, you may develop serious life-threatening side effects from the epinephrine in epinephrine auto-injector. Be sure to tell your doctor about all the medicines you take, especially medicines for asthma.
  • Patients with certain medical conditions, or who take certain medicines, may get more side effects from epinephrine auto-injector, or the side effects may last longer. This includes patients who take certain types of medicines for asthma, allergies, depression, hyperthyroidism, high blood pressure, and heart disease. Patients with heart disease may feel chest pain (angina). Patients with mental disease or Parkinson's disease may have worsening symptoms of their illness. Epinephrine auto-injector (epinephrine) can cause the following reactions. Some reactions can be serious. They usually go away with rest.
    • faster, irregular (wrong) or "pounding" heartbeat
    • throbbing headache
    • paleness
    • feelings of over excitement, anxiety, or fear
    • weakness or shakiness
    • dizziness
    • nausea and vomiting
    • sweating
  • These are not all the possible side effects of epinephrine auto-injector. For more information, ask your doctor or pharmacist.
  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.
  • After use/disposal
    • The remaining liquid that is left after this fixed dose cannot be further administered and should be discarded.
    • Put the auto-injector, needle first, into the carrying case.
    • Put the light gray case top over the non-needle end of the epinephrine auto-injector unit and close the case.
    • Give your used epinephrine auto-injector to a healthcare worker for disposal. Do NOT throw away in a regular trash can.

Click here for full Prescribing Information for epinephrine injection, USP auto-injector.

For more information about epinephrine injection, USP auto-injector, ask your doctor or call 1-888-894-6528. Ask your doctor if epinephrine injection, USP auto-injector is right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. Go to www.FDA.gov/medwatch or call 1-800-FDA-1088.