frequently asked questions about anaphylaxis and epinephrine auto-injector

Your healthcare provider has prescribed an epinephrine auto-injector for you because you have experienced a serious allergic reaction known as anaphylaxis, or you have been identified as at-risk. The epinephrine auto-injector is used for emergency treatment of life-threatening allergic symptoms. Although it can help save patients’ lives, use of an epinephrine auto-injector must be followed by emergency medical care.

Q. What are some of the allergic reactions that can cause anaphylaxis and require the use of epinephrine auto-injector?

A. Allergic reactions can be caused by stinging and biting insects (bugs), allergy injections, food, medicines, exercise, or unknown causes. Epinephrine auto-injector is an emergency injection (“shot”) of epinephrine. It is a medicine used for life-threatening allergic reactions such as severe swelling, breathing problems, or loss of blood pressure.

Q. How do I know when my epinephrine auto-injector expires?

A. You should check the expiration date often and obtain another auto-injector before it expires. The expiration date can be found in two places: on the auto-injector itself and on the side panel of the package in which your auto-injector came. Please refer to the training video to see the exact location.

Q. Does the epinephrine auto-injector deliver the same medicine as other epinephrine auto-injectors?

A. Yes. All epinephrine auto-injectors use the same medicine, called epinephrine. It is important to note that some devices may have unique features. It is essential that you become familiar with the features on your device so you are prepared in an emergency. Please refer to the training video to become familiar with how to inject the epinephrine auto-injector.

Q. Is the epinephrine auto-injector a substitute or authorized generic for other “branded” epinephrine auto-injectors?

A. Lineage Therapeutics’ epinephrine auto-injector is an authorized generic for Adrenaclick®. As to substitution, drug and generic drug substitution regulations are overseen by individual states. Since each state has its own laws and rules governing drug substitution, you should discuss the issue of substitution of an epinephrine auto-injector with your pharmacist and physician.

Q. Can I reuse my epinephrine auto-injector?

A. No, epinephrine auto-injector is only designed for a one-time use.

Q. Can I travel with my epinephrine auto-injector?

A. Yes, in fact, it is recommended that you always keep your auto-injector with you. Whenever traveling with your auto-injector, ensure that you follow the proper storage instructions. If you will be traveling by plane, it is suggested that you carry the epinephrine auto-injector in the original packaging and bring a letter from your physician that confirms your need to carry the auto-injector.

Q. After I used my auto-injector, I still see medicine remaining in my epinephrine auto-injector. Did I get my dose?

A. Yes, if the needle is exposed, you received your dose. The remaining liquid that is left after this fixed dose cannot be further administered and should be discarded. Promptly seek medical attention and give your device to a healthcare provider for proper disposal.

Q. Why is the epinephrine auto-injector available in two dosage strengths?

A. Selection of the appropriate dosage strength is determined according to a patient’s body weight. Each epinephrine auto-injector can deliver one dose of epinephrine in either 0.15 mg or 0.3 mg. The 0.15 mg dose is for patients who weigh approximately 33-66 pounds (15-30 kilograms). The 0.3 mg dose is for patients who weigh approximately 66 pounds or greater (30 kilograms or greater). Your doctor will carefully consider the dose that is right for you.

Q. Who is at risk for a life-threatening allergic reaction?

A. Anyone can experience a severe allergic reaction including anaphylaxis at any time. However, some people have risk factors that make them vulnerable to such a reaction. Consult your healthcare provider to see if you could be at risk for a severe allergic reaction, and if you should have a prescription for an epinephrine auto-injector.

Q. Should my child keep an epinephrine auto-injector at school?

A. Yes, your child, as well as appropriate school personnel (such as a nurse), should have access to an epinephrine auto-injector while at school. School personnel should always be informed of your child’s health status, history of allergic reaction and any specific triggers. School procedures vary, so be sure to understand the requirements for accessing your child’s epinephrine auto-injector at school. It is important that you understand the school’s policy with regard to the supply, storage, and expiration tracking. It is important that the epinephrine auto-injector is readily available in an emergency.

Q. Are trainer devices available for this product?

A. Yes. Training devices are available and free. You may order a trainer three different ways:

  1. You may click the green button HOW TO ORDER PRODUCT TRAINERS on any page of this website to order via the web.
  2. You may call 1-855-EPINEPH to order directly.
  3. You may complete the pre-paid business reply card available in the product packaging.

Q. What if I accidentally inject myself?

A. If you accidentally inject yourself, seek immediate medical attention.

Q. Where should I inject epinephrine auto-injector?

A. Epinephrine auto-injector should be injected into the middle of the outer side of your thigh (upper leg). It can go through clothes. Never inject into the buttock. Please see the training video for complete instructions.

Q. Where should I keep my epinephrine auto-injector?

A. It is recommended that you keep your epinephrine auto-injector with you at all times. However, be mindful that the auto-injector should be kept at room temperature (68°-77°F). There may be brief excursions to 59°-86°F. Do not refrigerate or freeze your auto-injector. Avoid extreme heat. For example, do not keep your auto-injector in your car.

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epinephrine and anaphylaxis FAQ
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Indication

  • Epinephrine auto-injector is an emergency injection ("shot") of epinephrine. It is a medicine used for life-threatening allergic reactions such as severe swelling, breathing problems, or loss of blood pressure. Allergic reactions can be caused by stinging and biting insects (bugs), allergy injections, food, medicines, exercise, or unknown causes.
  • After using epinephrine auto-injector go to your doctor or emergency room right away for more medical treatment.

Important Safety Information

  • Make sure to tell your doctor about all your medical conditions and allergies, but especially if you:
    • have heart disease or high blood pressure
    • have diabetes
    • have thyroid conditions
    • have asthma
    • have depression or other mental disease
    • have Parkinson's disease
    • are pregnant
    • are allergic to any of the ingredients in epinephrine auto-injector
  • Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Some medicines may cause serious side effects if taken while you use epinephrine auto-injector. Some medicines may affect how epinephrine auto-injector works, or epinephrine auto-injector may affect how your other medicines work. Diabetic patients may need to adjust the dose of their diabetes medicines or insulin after using epinephrine auto-injector.
  • Avoid injecting epinephrine auto-injector into your buttock or any other part of your body, other than the middle of the outer side of your thigh (upper leg). Avoid injecting epinephrine auto-injector into a vein.
  • Too much epinephrine (epinephrine auto-injector) can cause dangerously high blood pressure, stroke, or death. If you take certain medicines, you may develop serious life-threatening side effects from the epinephrine in epinephrine auto-injector. Be sure to tell your doctor about all the medicines you take, especially medicines for asthma.
  • Patients with certain medical conditions, or who take certain medicines, may get more side effects from epinephrine auto-injector, or the side effects may last longer. This includes patients who take certain types of medicines for asthma, allergies, depression, hyperthyroidism, high blood pressure, and heart disease. Patients with heart disease may feel chest pain (angina). Patients with mental disease or Parkinson's disease may have worsening symptoms of their illness. Epinephrine auto-injector (epinephrine) can cause the following reactions. Some reactions can be serious. They usually go away with rest.
    • faster, irregular (wrong) or "pounding" heartbeat
    • throbbing headache
    • paleness
    • feelings of over excitement, anxiety, or fear
    • weakness or shakiness
    • dizziness
    • nausea and vomiting
    • sweating
  • These are not all the possible side effects of epinephrine auto-injector. For more information, ask your doctor or pharmacist.
  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.
  • After use/disposal
    • The remaining liquid that is left after this fixed dose cannot be further administered and should be discarded.
    • Put the auto-injector, needle first, into the carrying case.
    • Put the light gray case top over the non-needle end of the epinephrine auto-injector unit and close the case.
    • Give your used epinephrine auto-injector to a healthcare worker for disposal. Do NOT throw away in a regular trash can.

Click here for full Prescribing Information for epinephrine injection, USP auto-injector.

For more information about epinephrine injection, USP auto-injector, ask your doctor or call 1-888-894-6528. Ask your doctor if epinephrine injection, USP auto-injector is right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. Go to www.FDA.gov/medwatch or call 1-800-FDA-1088.